Shifra Kholodenko (Russian: Шифра Наумовна Холоденко, Yiddish: שפרה כאלאדענקא) (1909-1974) was a Russian- and Yiddish-language poet, writer and translator from the Soviet Union.
She was born in 1909 as Shifra Hofshteyn (Yiddish: שפרה האָפשטיין, Russian: Шифра Наумовна Гофштейн) in Bartkova Rudniya, Volhynian Governorate, Russian Empire (today Bartukha, Zhytomyr Oblast, Ukraine; Ukrainian: Бартуха).
[5][4] Her brother, Dovid Hofshteyn, also became a well-known Yiddish poet and literary figure later in life.
Her first poems were published in 1922 in the Yiddish-language literary magazine Shtrom, which was edited by her brother Dovid.
During the Nazi invasion of the Soviet Union in 1941, her mother, father and brothers (excepting Dovid) were killed at Babi Yar.