[2][3][4] Bressler was born in Haifa, the second child of four, to a doctor mother and a father who was a senior worker at Elbit systems.

[6] In 2013, Bressler formed a team at the Weizmann Institute entrusted with the development of detectors and particle physics.

[3] Bressler heads a physics research group in the particle and astrophysics department of the Weizmann Institute and deals with the research into the Higgs Boson[3] In March 2020, Bressler founded and led the "Black Flag Protests", along with two of her brothers, Yarden and Eyal, and two family friends.

[4][1] Following the 2020 Israeli legislative elections, President Reuven Rivlin tasked the chair of the Blue and White party of forming a government.

Their second demand was the establishment of Knesset committees with parliamentary supervision, and the third demand was the legislation of an amendment to the basic law pertaining to the formation of a government and regulating government powers so that in the future, a person indicted on criminal charges would not be able to run for Prime Minister.

Former Prime Minister and protest leader, Ehud Barak, tweeted that Bressler's arrest was "dictatorship in action".

Knesset Member and Labor party leader, Merav Michaeli, stated that "in a normal country Shikma Bressler would be given the Israel Prize.

[18] The five day march from Kaplan Street in Tel Aviv to Jerusalem was a protest against the law proposal to reduce the reasonableness clause.