Shiraz University traces its roots to 1946, with the establishment of a technical college aimed at training specialists in the medical sciences with a four-year program.

At the Shah's request, Harnwell prepared a report entitled A Pattern for a New University in Iran, and the Shah subsequently decided that Penn would assist the Iranian government in transforming Pahlavi University[6] into the only institution in Iran based on American-style higher education.

[8] Harnwell and Penn assisted the Iranian government in establishing American-style higher education by supervising the new university's academic and administrative system in its early years.

[9] Many faculty members from Penn were sent to Pahlavi University to teach and carry out research, and a widespread exchange program was established.

[11] In 1962, Isa Sedigh became responsible for implementing the Ivy League's models at Pahlavi University.

Linus Pauling, scientist, peace activist, author, and winner of two Nobel Prizes, in Chemistry and Peace, came to Nowruz in Iran in 1975 at the invitation of the Iranian Society of Chemists to deliver a speech to the first Iranian Congress of Chemists.

The members of this board were the minister of the court, the minister of culture, the chancellor of the university, the governor of Fars, the CEO of the Planning Organization, the CEO of the National Iranian Oil Company, and between nine and fifteen others, competent cultural and financial personalities and captains of industry, chosen by the Ministry of Court and Culture, with the approval of Mohammad Reza Shah Pahlavi, and appointed for a period of six months.

[13] After the 1979 Islamic Revolution overthrew the Pahlavi dynasty, drastic changes were implemented at all universities.

Later in 1968 during the further constructing of the university campus and while Shiraz was getting ready to host its first Shiraz Arts Festival, many Iranian visual artists including Parviz Tanavoli, Sohrab Sepehri, Abolghasem Saeedi, Bahman Mohasses and Hossein Zenderoudi got involved designing artistic elements and wall paintings for the amphitheater, self-service dining and outside the campus.

In 1966, the New York based Asia Institute under Arthur Upham Pope re-established itself under the university supervision at Narenjestan Museum.

Before that, due to the Pope's close relationship with the Iranian royal family, the institute had autonomy, but after him, it went completely under the supervision of the Pahlavi University of Shiraz.

Among them, Houshang Nahavandi, then chancellor of Pahlavi University, claimed that Gluck, a member of the institute, was involved in smuggling Iranian antiques to Japan and demanded his removal.

On the other hand, after receiving the title of professorship from Harvard University, Frye had less time to attend the institute.

Abu Reihan Biruni Observatory was set up and established by Yousef Sobouti in collaboration with Edward Guinan and Robert H. Koch in 1975.

The idea pursued by Sobouti and in 1972, the telescope was finally ordered from the Astro Mechanics company in the United States of America with a cost of about 50K US dollars.

Also, in 1976, Iranian Lady Shahla Solhju, one of Iran's very first female professional astronomers, became the first co-director of Abu Reihan Observatory.

The total infrastructure of the current building of the Central Library and Documentation Center is about 11,000 square meters and is designed on four floors.

Kharazmi Library has one of the richest technical and engineering resources in the country and has a capacity of 700 people at a time.

It assumes a crucial role in catering to the diverse needs of affiliated entities, emphasizing sports and related activities.

These efforts collectively contribute to the development and promotion of sports culture within the university community.