The Shire covers an area of 7,027 square kilometres (2,713 sq mi), and its seat of government is the town of Manjimup.

The Shire area was first included in the Plantagenet, Wellington and Sussex Road Districts in 1871.

The Shire of Manjimup originated as the Warren Road District, which was gazetted on 3 July 1908, initially consisting of seven elected members.

[3] The Shire of Manjimup is located on the traditional land of the Bibulman and Mineng people of the Noongar nation.

The towns and localities of the Shire of Manjimup with population and size figures based on the most recent Australian census:[7][8][9] As of 2023, 271 places are heritage-listed in the Shire of Manjimup,[46] of which 16 are on the State Register of Heritage Places.