Following a move to Chicago, Mitchell appeared in the network radio broadcast of The First Nighter Program and played small parts in various soap operas, including The Story of Mary Marlin and The Road of Life.

After she moved to Los Angeles, she played opposite Joan Davis and Jack Haley in The Sealtest Village Store.

[3] Her most prominent radio role was that of the charismatic Southern belle Leila Ransom on The Great Gildersleeve beginning in September 1942.

Her rough-and-tumble character created a calamity in fancy places to the chagrin of guest stars Jimmy Stewart and his wife Gloria.

Between 1963 and 1965, she made five appearances on Perry Mason, including the 1965 episode "The Case of the Carefree Coronary," when she played Marilyn David, the widow of a murder victim.