Shirley Nathan-Pulliam (born May 20, 1939) is a former American politician from Maryland and a member of the Democratic Party.

While studying there she met her husband, a member of the United States Army, they married and moved to Baltimore, Maryland, in 1960.

While in the Maryland House of Delegates, Nathan-Pulliam served as a deputy majority whip and as a member of the Health and Government Operations Committee.

On January 30, 2023, her name was placed on the facade of the newest multi-million-dollar wing of the University of Maryland Nursing school.

On May 18, 2023, she accepted an honorary Doctor of Public Service Degree from the University of Maryland, Baltimore County.