She started her career as a nurse working in and managing emergency rooms in hospitals in Michigan.

[5] In 2007, she was selected as Mayo's chief administrative officer, becoming the first woman to serve as the organization's CAO.

As the CAO of Mayo, Weis is credited with changing the structure and the business model of the organization as well as introducing an enterprise-wide system for administrative and project management services.

In January 2014, she founded Weis Associates, a management and leadership development consulting firm.

[4] She regularly speaks at industry conferences and hosts national webinars on health care economics and marketing.

[12] She was inducted by the National Association of Professional Women (NAPW) as a 2015-2016 member of its VIP Woman of the Year Circle.