She is the only woman to represent the same constituency consecutively for three years in the Indian National Congress Party.

She was the first woman to be the Vice Chairperson of Kerala State Khadi and Village Industries Board and now hold the position of Chairperson for Oushadhi, the largest producer of Ayurveda Medicines in public sector in India operated by the Kerala Government.

[8] She filed her nomination as an independent, but withdrew at the last moment, citing pressure from the party.

[12] In 2002, a non-bailable arrest warrant[13] was issued for the arrest of Sobhana George,[14] in the case of a forged intelligence report which was faxed to the then Chief Minister A. K. Antony's office, stating that the Tourism and Fisheries Minister in his government, K. V. Thomas, was involved in a 366 crore Hawala transaction which took place in 1999–2000.

[citation needed] In 2011, Sobhana introduced a music album called 'Ente Onam' which was released by Chengannur Audios.

The movie is about child labor and has prominent actors such as Mukesh, Lakshmi Sharma and others.

Sobhana George is the only woman in the Malayalam Film Industry to carry out the Production, Scriptwriting, Dialogue - Writing, Screenplay and acting, all together in a single movie.