Constructed in stages between 1893 and 1902, the main part of the building was designed by local architect James Gilbert Chandler.

[5] After the passage of the Pure Food and Drug Act in 1906, which regulated the claims made by pharmacists like Shoop, the company was forced to cut back production.

By 1910, the Shoop laboratory's brand had been renamed Country Club Toilet Products, selling products under the lines: Country Club Toilet, Grecian Girl, Golf Girl, Min-u-et, Kathelee and Baby Love Talc.

[6][7] The rooms in the building were being rented to small companies like Western Publishing,[3] which had previously printed labels for Shoop's products.

[8] The Western Coil and Electric Company produced radios and pseudo-medical violet ray machines there during the 1920s.