Parikh gained notable roles for her portrayal as Aastha Agnihotri in the StarPlus romantic drama series Iss Pyaar Ko Kya Naam Doon?

[10] Parikh's first notable role was her portrayal as Aastha Agnihotri in the StarPlus romantic drama series Iss Pyaar Ko Kya Naam Doon?

Aastha is an extremely resilient and progressive girl who holds gender equality beliefs but unknowingly marries a chauvinist as he keeps her in a false pretence until their marriage night.

[11][12] Parikh appeared in the first Indian television spin-off series on StarPlus, Dil Boley Oberoi (2017), portraying Gauri Kumari Sharma opposite Kunal Jaisingh.

Her relationship with Omkara Singh Oberoi evolves from conflict to mutual respect and love, highlighting her ability to bring positive change to those around her.

[16] The Times of India noted: "Shrenu is a delight to watch on the big screen and share a pretty good onscreen chemistry with Jay Soni.

"[17] In 2019, Parikh played her first anti-heroine role with StarPlus's revenge thriller series Ek Bhram...Sarvagun Sampanna (2019) opposite Zain Imam.

[21] In 2022, Parikh shot a trailer promo for a Pratilipi FM horror thriller podcast, Chakia Ki Dayan with her former co-star, Avinash Sachdev.

Shrenu Parikh plays the role of a courageous and curious woman who finds herself drawn into the mysteries of the village of Chakia, which is haunted by the legend of a dayan (witch).

She is shown as a determined and fearless character, driven by a strong sense of justice and a desire to uncover the truth behind the supernatural events plaguing the village.

[24][25] In December 2023, Parikh married her co-star from Ghar Ek Mandir – Kripa Agrasen Maharaj Ki, Akshay Mhatre, in a traditional Hindu wedding ceremony in Vadodara.