It specializes in orthopedics, cleft lip, and palate disorders as part of the 22-hospital system belonging to the Shriners Hospitals for Children.

[6] In 1948 to support the hospital, the local Shriners started the North South high school all-star Oregon Shrine Game, which later became the Les Schwab Bowl.

[15] Construction began in September 2008 to add a four-story extension of the hospital over the parking garage in a project expected to cost $70 million.

[20] Shriners Hospital serves patients from Oregon, Idaho, Washington, Alaska, and British Columbia regardless of the family's ability to pay.

[22] Portland Shriners specializes in orthopaedic and cleft lip and palate conditions, but also has services for rheumatoid arthritis and post-care for burn patients.