The Shriner's Hospital for Children, along with McGill University was named number 1 in the world in expertise in Osteogenesis Imperfecta (OI) with researchers Frank Rauch ranked #1 and Francis H. Glorieux #3 in global expertise in Osteogenesis Imperfecta (OI).

[1] The hospital opened at its original location on February 10, 1925 when it received its first patient: 10 year old Harvey Jones from Haileybury Ontario.

It was felt an Ottawa location would not greatly affect access to those in the US Northeast, or eastern Canada, only being about 200 km from Montreal.

The president of the Shriners brought up the potential threat of Quebec separation to influence the move out of the province.

On October 13, 2011, the official ground breaking ceremony for the new Shriners hospital took place, on the site of the MUHC superhospital.