Si Lom was one of the earliest modern roads to be built in the city, and some of its side streets serve historic ethnic neighbourhoods from the late nineteenth century, while others are known as shopping and nightlife venues.
[4] The BTS Skytrain, opened in 1999, now runs above the eastern half of the road's length, and Si Lom and Sathon continue to be known as one of the main business districts of Bangkok.
Most of the road is fronted by commercial establishments, with its eastern half in particular lined by towering office blocks and luxury hotels, while several distinctive neighbourhoods are nestled along its side streets (soi).
Near the Sala Daeng end, the streets serve a concentration of nightlife venues, and blend into the tourist-oriented red-light district of Patpong, while Thaniya (ธนิยะ, also spelled Taniya) is known as a hub of Japanese establishments.
The street is officially named after Pan Watcharapai née Na Songkhla (ปั้น วัชราภัย (ณ สงขลา)), who was the wife of Luang Uppakankosakon (หลวงอุปการโกษากร) and provided the land for its construction.
Other significant buildings include the nearby Jewelry Trade Center, and King Power Mahanakhon on Naradhiwas Rajanagarindra Road.
The 1981 headquarters building of Bangkok Bank is iconic for its pioneering application of modernist design to a concrete high-rise building, while other major corporations based on Si Lom include Thailand's largest conglomerate Charoen Pokphand and other financial institutions, leading Si Lom to be known as the "Wall Street of Thailand".