"Si Supieras" was written by Daddy Yankee, Wisin, Yandel, Rafael Pina, Eric "Lobo" Rodríguez, Juan "Gaby Music" Rivera, Francisco "Luny" Saldaña, and Marco "Tainy" Masis, and was produced by Daddy Yankee's and Wisin & Yandel's longtime collaborators Luny and Tainy.

[3][4][5] Puerto Rican producer Tainy took part on the production of every studio album by Wisin & Yandel since Pa'l Mundo and won a Latin Grammy Award for Best Urban Song with them for "Abusadora" in 2009.

[9] "Si Supieras" is the ninth collaboration between Daddy Yankee and Wisin & Yandel, following other singles including "No Me Dejes Solo" (2004), "Mayor Que Yo" (2005), "Noche de Entierro" (2006), "Mayor Que Yo 3" (2015), and "Todo Comienza en la Disco" (2018).

[10][13] Wisin described "Si Supieras" as a romantic song, similar to "No Me Dejes Solo" from Daddy Yankee's album Barrio Fino.

[13] The music video for "Si Supieras" was directed by Venezuelan director Nuno Gomes, who had previously worked with Daddy Yankee on "Andas En Mi Cabeza" (2016) and "La Rompe Corazones" (2017) and also with Wisin & Yandel on "Duele" (2019).