The source of most of Howie's frustration was his wife's younger sisters (the siblings, or "sibs", of the title), Audie (Margaret Colin) and Lily (Jami Gertz).

Nora's late boss had left the firm to his boorish, whiny nephew Warren Morris (Dan Castellaneta), who was another ongoing character.

The series' low ratings adversely affected the shows that followed it, Anything but Love and Good & Evil, another freshman comedy, which, in its own right, was struggling due to its 10:30/9:30c scheduling and controversy over its storylines.

Perlman was successful in having Margaret Colin, Jami Gertz and Dan Castellaneta participate in the new pilot, in which all reprised their Sibs characters of Audie, Lily and Warren respectively.

Warren, whose character had also become more subdued, was a companion of the girls, while the new supporting cast included Mark Nassar as Audie's frantic, entrepreneurial boss Michael Brickman and Grayson McCouch as Henry, Lily's assistant in a catering business.