A Roman raid from Martyropolis triggered the Sasanians to launch a siege on the newly fortified frontier city.

Both Belisarius and Azarethes, the Byzantine and Sasanian generals at Callinicum, respectively, were dismissed due to the high casualties of this battle.

This led the Sasanians to lay siege on Martyropolis with a capable force under three veteran generals, Adergoudounbades ("Chanaranges"), Bawi ("Aspebedes"), and Mihr-Mihroe.

Sittas and his Ghassanid ally Al-Harith ibn Jabalah were stationed near the city, but avoided engagement since the Persians had the upper hand in the conflict.

However, a series of political events, including the death of Kavadh I and the perceived threat of Huns, as well as the arrival of winter and the presence of Roman reinforcements at Amida all led the Sasanian field commanders to abandon the siege and agree on an armistice.