The first siege of Thessalonica took place between 1383 and 1387 between the Ottoman army dispatched by Murad I and the Byzantine garrison led by Manuel II Palaiologos.

Manuel II, the son of John V Palaiologos, rebelled against his father and established an independent regime in Thessalonica in November 1382.

He exhorted them with a speech to encourage them to resist the Ottomans with all their power and hoped an honorable peace would be established.

The population wasn't satisfied with his speech as many of them preferred to surrender to escape pillage and destruction.

This angered Sultan Bayezid I, who laid waste to the remaining Byzantine territories Thessalonica too submitted again to Ottoman rule at this time, possibly after brief resistance, but was treated more leniently: although the city was brought under full Ottoman control, the Christian population and the Church retained most of their possessions, and the city retained its institutions.