The team participates in the Metro Atlantic Athletic Conference (MAAC).

The team plays its home games at Siena Softball Field located on the university's campus.

[3] Since joining the Metro Atlantic Athletic Conference in 1990, the Saints have managed to win one regular season title, doing so in 2013 in a tie with Fairfield.

[4][5] Despite their successful 2013 regular season, the Saints failed to win the MAAC tournament championship, losing their opening game to Niagara and were eliminated by Fairfield.

[8][9] The team has also won three MAAC Softball Player of the Year awards, winning in 2012 with Shannon Jones and in 2017 and 2019 with Madysen Cossack.