Siena College of Quezon City is a private, sectarian, non-stock basic and higher education institution run by the Congregation of the Dominican Sisters of St. Catherine of Siena in San Francisco del Monte, Quezon City, Philippines.

In the mid-1950s, the idea of setting up another school within the compound of the Motherhouse located in the then rugged fields of San Francisco del Monte was conceived in response to the education needs of the growing community in the area.

Natividad Pilapil, O.P., the Superior General of the Congregation, construction of the first building along Del Monte Avenue was started in 1958.

At this time, the grade school adopted the Individualized Group-Guided Education (IGGE) program.

A unique and highly systematized program, the CS-SD consists of different phases of continuing development for Catholic schools with emphasis on the formation of personnel into other Christ through a radical living of the Gospel and the improvement of education services through Christ-like operations.

In October 1982, the three departments of Siena College underwent the first Congregational Evaluation Visit (CEV), which is part of the CS-SD program.

The following new programs were opened in 2003: the Caregiver course to enhance the development of skilled human resources in the health, social and other community development services and the Special Education program to provide conducive learning environment and facilities for special children.

As a PAASCU member since 1980, Siena College, QC was granted again five-year re-accreditation status to the three departments in AY 2005–2006.