It is located at Golden Acres Road, Corner Misamis Street, Bago-Bantay, Quezon City, Philippines.

However, in 1969, the school relocated to the site of the former San Jose Seminary, which the Quezon City General Hospital is currently located.

In 1976, a two-story semi-concrete six-room building was constructed with the representation of the former Schools Superintendent Commemoracion M. Concepcion to the Quezon City Board.

Another two-story six room concrete science building was finally completed in 1983 through the then City Mayor Adelina S. Rodriguez and the incumbent Division Superintendent, Dr. Edna B. Azurin.

Between 1995 and 1997, more rooms were constructed, including Mathay Hall, Icasiano-Calalay, DOST Chemistry, and Physics laboratory buildings.

In 1999, Mayor Ismael A. Mathay Jr. spearheaded the construction of a four-story sixteen-room concrete building, and Dr. Aquilina S. Rivas, the Schools Division Superintendent, oversaw the renovation of the DOST Laboratory.

This led to the introduction of a new screening process for incoming freshmen, initiated by the Division of City Schools under Dr. Aquilina S. Rivas' leadership.

Changes in the curriculum led to improvements in school facilities, including the construction of new buildings, rehabilitation of the football field, and the transformation of the Covered Court into a modern structure housing new laboratories and a gymnasium.

Graduating Grade 6 elementary pupils from public and private schools in the National Capital Region (NCR) who meet the following criteria are eligible to apply for QCSHS Qualifying Examination.

Placing and reigning over quiz bees abroad also happens a lot during every school year, especially in core science subject areas (Biology, Physics, Chemistry etc.).

QueSci has a parking lot that snakes around the inside of the campus, 2 gates (Scientian/Golden Acres Road & Misamis St.), and 9 buildings.

In 2009, during the sacking of publications supervised by adviser Rex San Diego, several students vented their angst on the Internet against principal Zenaida Sadsad.

2) openly endorsing Brainworks/Brainchamps Tutorial Learning Center to QCSHS student applicants, with the assurance of guaranteed admission slot in the school.