He was lord of San Martino in Rio, Campogalliano, Rodeglia, Castellarano and San Cassiano, governor of Reggio, governor and duke's lieutenant of the duchy of Ferrara and captain-general of the duke of Ferrara's army.
He was born in Ferrara, the second son of Niccolò III d'Este and his third wife Ricciarda di Saluzzo.
In 1434 he was christened and armed as a knight of his godfather Sigismund, Holy Roman Emperor.
Borso was succeeded by Sigismundo's elder brother, who kept on Sigismondo as lieutenant of Reggio Emilia and had him rule the duchy when he was absent.
[3] He had three daughters with his wife Pizzocara: He also had a natural son (later legitimized) with Cecilia di Rachesi da Rezo:[4]