22 May 1452) was a German prince of the House of Ascania and ruler of the principality of Anhalt-Dessau.
He was the fourth son of Sigismund I, Prince of Anhalt-Dessau, by his wife Judith, daughter of Gebhard XI, Count of Querfurt.
By virtue of the family of law of the House of Ascania, there was no division of territories among them.
Sigismund married Matilda (died 1443), daughter of Bernhard VI, Prince of Anhalt-Bernburg.
Without direct heirs at the time of his death, Sigismund was succeeded by his surviving brothers and co-rulers.