Signe Wilkinson (born July 25, 1950, in Wichita Falls, Texas) is an editorial cartoonist best known for her work at the Philadelphia Daily News.

This job shortly ended due to a coup d'état in Cyprus, followed by a military invasion from Turkey.

In 1982, she earned a full-time job at the San Jose Mercury News, where she spent three and a half years working as a cartoonist.

[11] Wilkinson has also created cartoons for Working Woman, Ms., Organic Gardening, the Institute for Research on Higher Education and several other publications, such as the Friends Journal and the University Barge Club newspaper.

[9][13] On November 21, 2007, Wilkinson launched a syndicated daily comic strip with United Media entitled Family Tree.

For Organic Gardening magazine, Wilkinson created a comic strip entitled Shrubbery that centered on botanical and political topics.