It was not until later in 1903 that a hospital was formally built in replace of it, by the American missionary doctor, Henry Langheim together with his wife who was also a medical practitioner as founders.

As Japanese activity stepped up, the evacuation hospital had to close, and Dr Garcia joined the resistance in the interior mountains of Negros island where American missionaries and their families, SU faculty staff, and students operated throughout the duration of the war.

In 1974, a cornerstone for the present hospital's location on Aldecoa Drive, was laid down to commence the building of a four-storey modern healthcare facility with passenger elevators, the first in Negros Oriental.

SU Medical Center made a milestone in 1979 when its Van Houweling Research Laboratory discovered and produced a dog vaccine that gave a three-year immunity from rabies.

It also serves as a base hospital and medical care provider for the faculty and staff members, personnel, students and alumni of Silliman University.