As an actress Pretorius is best known for portraying Irma Humpel in the 2016 Afrikaans biographical film Vir die voëls,[2] for which she gained prominence and international recognition.
[3] In 2024 she makes her screenwriting and directorial debut for the award-winning, "Som van Twee", that won seven awards at the Cape Town Silwerskerm festival, including for Best Director and Best Screenplay.
[4] Her mother, Tinkie Nortmann,[5] noticed her daughter's passion for acting when she one day climbed on top of KFC’s counter and started performing for the patrons.
[7] In 2015 she attends a three-week acting workshop led by Academy Award nominee and Broadway regular, Diane Venora, in California.
[19] Thereafter Simoné starred as Krizanda in "Swartwater" (2020), Chanel in MNET's telenovela, "Legacy" [20](2022) and a lead in KykNET's procedurial drama, "Hartklop", as Dr Elani Breytenbach (2023).