[1] In 2006 he achieved a fourth place in at the national competition of Standup, and chose to leave his childhood city Skanderborg and moved to Copenhagen to develop his career as a stand-up comedian.

In 2009, he participated in Comedy Aid, which collects money for Kræftens Bekæmpelse (Danish Cancer Society).

[2] In March 2010, he starred as a co-host and writer, together with the comedian Jacob Wilson, on the national TV show Bingo Banko.

[4] In 2019, Simon Talbot made a stand-up set on The Russell Howard Hour, with the clip on YouTube amassing over one million views.

The highlights of the streams are later published on his YouTube Channel, and social media pages such as Facebook, Instagram and Twitter.

The tour of the show was marked as a mini-tour since Simon only visited the towns of Aarhus, Aalborg, Frederiksberg, Vejle, Odense, Holstebro, Sønderborg and Esbjerg.

[7] The second one-man show by Talbot was "Talle alene i verden" (in English: 'Talle alone in the world'), which was a reference to a danish children's book.

Mr. Copenhagen was Simon Talbot's third one-man show and the theme was built around the stereotypes of Danish society.

In 2017, Talbot started pursuing his long-time dream doing comedy in English and moved to Los Angeles, USA.

In 2018 he made his fourth one-man show "Make Denmark Great Again", where he tells the story of his first international experience.