Simon Picone (born 26 September 1982) is an Italian rugby union player for Benetton Treviso in the Pro14 competition.
He was born in Viterbo.
A Scrum-half, Picone was called up to the Italy squad for the 2008 Six Nations Championship.
He came off the bench in Italy's 23–19 defeat to England in Rome to run in a try after charging down debutant England fly-half Danny Cipriani's kick.
This biographical article relating to Italian rugby union is a stub.