Brambilla led the women's branch of the Consolata Missionaries from 2011 to 2023 and became the first female secretary of the Dicastery for Institutes of Consecrated Life in October 2023.

She obtained a diploma in nursing 1986[1] and worked at the L. Mandic Hospital in Merate (Province of Lecco).

[2] She entered the Institute of the Missionary Sisters of Consolata in 1988 and made her first religious profession in 1991.

[1] Beginning in 1999, after making her final profession, she was responsible for youth ministry at the Macua Xirima Study Center in Maua, Mozambique.

[9] On December 13, 2024, Pope Francis named her and María Lía Zervino along with two cardinals as his appointees to the 16th Ordinary Council of the General Secretariat of the Synod.