Simona Isidori (born 10 October 1967) is an Italian former professional tennis player.

Isidori reached a career high singles ranking of 195.

Her best WTA Tour performance was at the 1989 Spanish Open, where she won through to the second round.

[1] She featured in the qualifying draws for both Wimbledon and the US Open in 1989.

As a doubles player, she claimed two $25,000 ITF titles, both in 1990 partnering Silvia Farina Elia.