Simone Karpani (born 16 June 1997) is an Australian professional rugby league footballer who currently plays for the Newcastle Knights in the NRL Women's Premiership.

Born in Logan, Queensland, Karpani played her junior rugby league in Adelaide, South Australia.

[8] In round 1 of the delayed 2021 NRL Women's season, she made her NRLW debut for the Roosters against the Brisbane Broncos.

[2] She made her club debut for the Knights in round 1 of the 2022 NRLW season against the Brisbane Broncos.

[11] On 2 October, Karpani played in the Knights' 2022 NRLW Grand Final win over the Parramatta Eels.