Simple Sis is a 1927 American silent comedy-melodrama directed by Herman C. Raymaker and starring Louise Fazenda as a poor, plain laundress hoping for romance, supported by Clyde Cook as a shy suitor and Myrna Loy as a cruel beauty.

When attractive Edith Van inadvertently hides her love-letter in the wrong pocket, Sis finds it and, thinking it is for her, goes to meet the lover.

[6] Variety summed up the production as "colorless" and "of negligible entertainment or box office value".

[7] The reviewer for Motion Picture News called it "hokum" and thought it came across as depressing rather than comedic.

[8] In the brief Photoplay review, audiences were warned of boredom and Fazenda was deemed "worthy of better stories".