[6] Simpsonville is part of the "Golden Strip", along with Mauldin and Fountain Inn, an area which is noted for having low unemployment due to a diversity of industries including H.B.

Simpsonville is named after Peter Simpson, a farmer from Laurens County who provided blacksmithing services and became the local postmaster.

[7][8] The Burdette Building, Cureton-Huff House, Hopkins Farm, and Simpsonville Baptist Church are listed on the National Register of Historic Places.

[11] In October 2018, a winning lottery ticket for a $1.6 billion Mega Millions jackpot was sold at the #7 KC Mart in Simpsonville.

[12] Simpsonville is located in southeastern Greenville County at 34°44′0″N 82°15′36″W / 34.73333°N 82.26000°W / 34.73333; -82.26000 (34.733375, -82.260001),[13] between Mauldin to the northwest and Fountain Inn to the southeast.

[19] In September 2007, the FBI reported that the state of South Carolina's violent crime rate was the highest in the nation per capita, although Simpsonville is not mentioned at all in the article.

In 2017, Simpsonville was named the safest city in South Carolina, based on FBI Crime Report data gathered by the SafeWise security organization;[21] its ranking as of 2021 is 15th.

Protection is provided to citizens within Simpsonville's city limits and some parts of surrounding Greenville County via six fire stations within a district of about 30 square miles (78 km2).

[31] The current city officers include:[32] Public education in Simpsonville is administered by Greenville County School District.

[39] Simpsonville's CCNB Amphitheatre at Heritage Park, named for sponsor Coastal Carolina National Bank, is an outdoor entertainment venue with seating for up to 15,000.

[41][42][43] The Women's American Basketball Association established a team based in Simpsonville to begin its first season in July 2021.

Local television stations include: Simsponville is part of the Greenville-Spartanburg-Anderson Arbitron Metro radio market.