When he was seven, his parents separated, and he lived with his mother on a number of different farms during his childhood, going to school in Indian Head, Saskatchewan.
At first, he worked in a number of small towns in Saskatchewan, then moved to Winnipeg, Manitoba in 1933 where he wrote and published his most famous novel As For Me and My House.
He remained with the Royal Bank until his retirement in 1968, after which he spent some time in Spain and Greece before moving to a nursing home in Vancouver, British Columbia, where he lived until his death.
[2] A monument in his honour has been erected in Indian Head by Saskatchewan artists and readers, with a bronze statue sculpted by Joe Fafard.
The year after his death his homosexuality became public knowledge for the first time, as a result of Keath Fraser's biography As For Me and My Body: A Memoir of Sinclair Ross (1997).