Raghab Narendra Sen, who was the King of Makwanpur in 1530 and known as the Sindhuli, established the settlement of the region and thus it was named after him.

[2] ii) At ancient time the great saint used to dwell in the hill (1077 m above sea level) of nowadays Sindhuli madi.

These indigenous people call Singthuwa (सिङ्थुवा) for cutting down tree and Sinthuji (सिङ्थुजी) for collecting timber.

The army under the leadership of Captain Kinloch came to help the then ruler of Kathmandu - Jai Prakash Malla against the attack of Prithvi Narayan Shah.

However, in recent years, due to a lack of maintenance, the district mainly preserves remnants of the past.

[citation needed] At the time of the 2011 Nepal census, Sindhuli District had a population of 296,192.

[4] Ethnicity/caste: 27.0% were Tamang, 14.8% Magar, 13.6% Chhetri, 7.8% Hill Brahmin, 6.3% Newar, 5.9% Danuwar, 4.6% Kami, 3.6% Sarki, 3.5% Majhi, 3.1% Damai/Dholi, 2.7% Sunuwar, 1.5% Gharti/Bhujel, 1.0% Rai, 0.6% Hayu, 0.6% Musahar, 0.6% Thakuri, 0.5% Sanyasi/Dasnami, 0.3% Pahari, 0.3% Sudhi, 0.3% Thami, 0.2% Terai Brahmin, 0.2% Gurung, 0.1% Bhote, 0.1% Kalwar, 0.1% Sonar, 0.1% Teli and 0.2% others.

Science college like Kamala Higher Secondary School is providing good practical based education to students of Sindhuli.