Sinking Creek begins in the Bear Meadows Natural Area in a valley in Harris Township.
Some distance later, it crosses Pennsylvania Route 144 and receives the tributary Potter Run.
A few miles further downstream, it passes north of Egg Hill, and then reaches its confluence with Penns Creek at the community of Spring Mills,[2] 58.82 miles (94.66 km) upstream of the mouth of Penns Creek.
[3] It is possible to canoe on at least 6.9 miles (11.1 km) of Sinking Creek during snowmelt or within one week of heavy rain.
Edward Gertler describes the scenery along the creek as "good" in his book Keystone Canoeing.