The Sinkiuse-Columbia are a Native American tribe so-called because of their former prominent association with the Columbia River.

They belong to the inland division of the Salishan group, with their nearest relatives being the Wenatchis and Methows.

They apply the name to other neighboring Interior Salish peoples, potentially originating from a band that once inhabited the Umatilla Valley.

[2] In 1870, Winans placed them "on the east and south sides of the Columbia River from the Grand Coulee down to Priest's Rapids."

Other Interior Salish Southern dialects, were spoken by Pisquow, Wenatchi, and Methow.