Sir Charles Mansfield Clarke, 1st Baronet, FRS, FRCP (28 May 1782 – 7 September 1857) was a British surgeon.

He was grandfather to General Sir Charles Mansfield Clarke, 3rd Baronet GCB GCVO.

After a further period as surgeon with the 3rd Foot Guards, he left the army and, on his brother’s persuasion, specialised in midwifery and in women’s and children’s diseases.

[3] Sir Charles was Royal Physician to Queen Adelaide, wife of William IV.

As a result, he was created a baronet, of Dunham Lodge, in the County of Norfolk in the United Kingdom on 30 September 1831.