He constructed the older sections of Van Manor, located near Caerphilly in Glamorganshire, Wales, and established the estate's park.

Additionally, he acquired the manor of Roath-Keynsham, part of the former estate of Keynsham Abbey, enhancing his family's holdings.

[1][page needed][2] Lewis served as Sheriff of Glamorgan on three occasions—in 1548, 1555, and 1559—demonstrating his prominent role in local governance and his influence within Welsh society.

He was married to Ann Morgan, the daughter of Sir William Morgan of Pencoyd, Monmouthshire, a member of the notable Tredegar family.

Their marriage linked the Lewis family to the Morgans of Tredegar.