In 1621, Sir Edward was born at Hayton Castle in Cumberland, England to Dr. William Musgrave (1585-1634) and Lady Catherine Sherbourne (1589-1649).
[2] Of note, his eldest daughter became Lady Jane (1643-1677) when she married Sir Wilfrid Lawson, 1st Baronet, of Isell.
As of 1638, Sir Edward Musgrave, 1st baronet of Nova Scotia was an ardent Royalist.
During the English Civil War, he spared neither person nor fortune, heavily investing both of his own accord.
Wanted by Parliament, when his refuge was discovered, Cromwell informed the Duke that “if he did not forthwith deliver up Ned Musgrave he would send a troop of horse to storm his castle.” Musgrave escaped and fled to the Isle of Man.