Sir Francis Nicolls, 1st Baronet (sometimes spelt Nichols) (1586 – 4 March 1642) was an English Member of Parliament.
He was born the eldest son of Francis Nichols of Hardwick, Northamptonshire and was educated at Brasenose College, Oxford.
He also entered the Middle Temple in the same year (1602) to study law but was never called to the bar.
He succeeded his father in 1604 and inherited land at Faxton in 1616 on the death of his uncle, the judge Sir Augustine Nicholls.
In 1628 he was elected MP for Northamptonshire, sitting until Parliament was suspended the following year by King Charles I.