James Hamilton, baptized on 24 November 1682, was the third, but eldest surviving son of Sir Archibald Hamilton, 1st Bt., of Rosehall by his 2nd wife Bethia, daughter of Sir Patrick Murray of Deuchar, Forfar.
James married on 2 March 1707, Frances, daughter of Alexander Stuart, 4th Lord Blantyre He succeeded his father as 2nd Bt.
[1] A Lanarkshire Justice of the Peace, he was returned Member of Parliament without a contest for Lanarkshire in 1710 with the support of the Duke of Hamilton.
[2] He died childless on 15 March 1750 and the estate and baronetcy passed to his brother Hugh, who died unmarried in 1755.
The title became extinct and Rosehall passed first to Hamilton’s half-sister, Margaret, and thereafter to her eldest son, Archibald Hamilton of Dalzell.