He was created a baronet in June 1620, and sat in Parliament for Aylesbury in 1623–1624.
Pakington died in October 1624, and was buried at Aylesbury.
[1] Sir John married Frances, daughter of Sir John Ferrers of Tamworth, with whom he had two children, a son John (1620–1680), who succeeded to the title, and one daughter (Elizabeth), who married, first, Colonel Henry Washington, and, secondly, Samuel Sandys of Ombersley in Worcestershire.
His widow, Frances, married at St. Antholin, Budge Row, London, on 29 December 1626, "Mr. Robert Leasly, gent.
"[2] The similarity of name may account for the incorrect statement sometimes made that she became the second wife of Alexander Leslie, 1st Earl of Leven.