[3] Howe was returned unopposed as Member of Parliament (MP) for Hindon at the general elections in February and August 1679 and sat until January 1681.
He refused to sign the Association in February 1696, and opposed fixing the price of guineas at 22 shillings in March.
At the 1705 English general election, he was returned again for Wiltshire, and voted against the Court candidate for Speaker on 25 October 1705.
He was busy sorting out the complicated affairs of Sir Humphrey Mackworth's Company of Mine Adventurers and in raising the complaints of its proprietors and creditors in Parliament.
He had no children and left his main estates in Wiltshire and Gloucestershire to his cousin John Howe, 1st Baron Chedworth of Somerset.