Sir William Glynne, 2nd Baronet (17 May 1663 – 3 September 1721) was a Welsh lawyer and politician.
The elder son of Sir William Glynne, 1st Baronet (whom he succeeded in 1690), he was educated at St Edmund Hall, Oxford.
He was Member of Parliament for Oxford University from 1698 until 1701 and then represented the borough of Woodstock from 1702 until 1705.
from Oxford in 1706 and was appointed High Sheriff of Oxfordshire for 1706–7.
They had two children: Predeceased by his only son, he was succeeded on his death in 1721 by his brother Stephen.