[1] He spent his early years in Kakinada, where he developed his literary skills under the guidance of his father, Chembolu Venkata Yogi, a polyglot.

[citation needed] He wrote lyrics for many songs in films such as Swayam Krushi, Swarna Kamalam, Samsaram Oka Chadarangam, Shrutilayalu, and Pelli Chesi Choodu.

[citation needed] He followed up with lyrics for songs in films such as Shubha Muhurtam, Priya Raagaalu, Aahaa..!, Pelli Kanuka, Sindhooram, Aavida Maa Aavide, Chandralekha, Wife of V. Varaprasad, Seetharama Raju, Prema Katha etc.

His lyrics received positive reception and won him his seventh and eighth Nandi Award for Best Lyricist for the songs "Ardha Shatabdapu" (Sindhooram) and "Devudu Karunistadani" (Prema Katha).

[citation needed] He started 2000s by writing lyrics for films such as Murari, O Chinadana, Okkadu, Nuvve Kavali, Nuvvu Naaku Nachav, Manmadhudu, Ela Cheppanu, Varsham, Nuvvostanante Nenoddantana, Chakram, and Happy.

Among these songs, "Hare Rama" (Okkadu), "Ekkada Unna" (Nuvve Kavali), "Aakasam Thakela" (Nuvvostanante Nenoddantana) and "Jagamantha Kutumbam" (Chakram) got positive reception with "Aakasam Thakela" winning him his first Filmfare Award for Best Lyricist – Telugu and "Jagamantha Kutumbam" winning him his ninth Nandi Award for Best Lyricist.

[citation needed] He followed up by writing lyrics for many songs from films such as Bommarillu, Aadavari Matalaku Ardhalu Verule, Gamyam, Sasirekha Parinayam, Jalsa, Parugu, Kotha Bangaru Lokam, Mahatma etc.

[8] Seetharama Sastry is known to have a long time association with banners Annapurna Studios and Sumanth Art Productions and directors K. Viswanath, Ram Gopal Varma, Krishna Vamsi and Trivikram Srinivas.

With K. Viswanath, he has worked on many films including his debut venture Sirivennela, Sruthilayalu, Swayamkrushi, Swarna Kamalam, Aapadbandhavudu, Swati Kiranam, Subha Sankalpam etc.

The films for which Sitarama Sastry wrote lyrics, which were directed by Krishna Vamsi include Ninne Pelladatha, Gulabi, Sindhooram, Chandralekha, Murari, Khadgam, Chakram, Mahatma etc.

Some examples of this kind of song include "Aakasam Thakela" (Nuvvostanantey Nenoddantana, Prabhu Deva's directorial debut), "Entha Varaku" (Gamyam).

He was often considered the most versatile Telugu film lyricist working because he has contributed lyrics for songs comprising all kinds of genres like duets, hero introduction, romantic, devotional, thought provoking, lighter vein.

[10] In summer of 2014 along with singers Parthasaradhi (Parthu) and Sahithi, he toured many cities in United States presenting the concept behind the lyrics called "Sirivennela Antharangaalu".