[3] In 2012, Sirusho released the single "PreGomesh", which inspired her to launch a range of handcrafted silver jewelry of the same name, representing Armenian culture and craftsmanship mixed with modern fashion trends.

[6][7] In 2017, Sirusho was awarded with the title of Honored Artist of Armenia upon the decree of President Serzh Sargsyan.

She subsequently studied piano at the Sayat-Nova Music School[10] and graduated Yerevan State University with excellence in international relations.

[1] "I have worked and toured a lot this year, and even in a few hours after this event, I'll be flying to the U.S. for concerts, and i want to thank all of you for giving me the wings for all future flights in my life" Although Sirusho mainly performed soul and pop for most of her career, she decided to work on an album of Armenian folk songs by gusan titled Sheram, which was released in 2005.

A few days later, she released her single "Heranum em" (Armenian: Հեռանում եմ) (I am leaving), which soon became a hit.

[19] In 2009 Sirusho recorded a song dedicated to peace along with the participants of Eurovision 2008; Boaz Mauda and Jelena Tomasevic, representing Israel and Serbia, respectively.

At the end of February she was invited to Malta as a special guest to perform at the Maltese Eurovision selection.

During the visit she appeared on local television shows and took part in the Maltese annual charity, performing Havatum em.

[25] In the same month, Russian singer Grigory Leps released his new album featuring the song “Судьба Зима” written by Sirusho.

Mixing traditions of different generations, Sirusho released the remake of "Tariner" (Armenian: Տարիներ) ("Years") with her compatriot Harout Pamboukjian.

[32][33] In the same month Sirusho announced the upcoming release of her new album called Armat (Root) that would represent the Armenian culture.

[34] In 2017 Sirusho released a new summer hit song "Vuy Aman" together with Armenian-American singer, songwriter, Sebu Simonian of the Capital Cities band.

[35] She performed at the opening ceremony of the 2019 CONIFA European Football Cup in the de facto Republic of Artsakh.

[36] In 2021, Sirusho released a collaboration single titled "Stay" featuring Norwegian singer Alexander Rybak, who won the 2009 Eurovision Song Contest.

[37] In 2022, Sirusho has participation in the creation of foundation named after Armenian eminent and beloved artist Hayko.

[43] Following the display, The National Security Committee of Azerbaijan seized tele-voting records and interrogated forty-three Azerbaijani citizens that voted for Armenia that year.

[44] During the 2020 Nagorno-Karabakh War, she stated on social media that her husband was "in Artsakh" and she would be engaging in volunteer efforts at the border.

The music video, as well as documentary footage covering its recording, was done on iPhones, sparking controversy in Turkey.