[1] Khao Phra Wihan National Park covers an area of 130 km2 of the Dângrêk mountains in the southeast of the province.

Access to the temple is still principally from the Thai side, as the ruins are difficult to reach from the Cambodian plains at the bottom of a sheer cliff several hundred meters below.

The Cambodian government has expressed interest in building a cable car to carry tourists to the site, though this has yet to happen, pending resolution of the ownership of other areas in the Cambodian–Thai border dispute.

It was later called Khukhan, after a town built in the late-15th century CE during the reign of King Boromaratcha III of Ayutthaya.

Ethnic Laos began settling the northern portion of the province, and in 1786 the town Sisaket was formed, subject to Khukhan.

Five years later, the name of the town and province were restored to Sisaket, with the district containing Huai Nua being called Khukhan.

[citation needed] The province is populated by four main ethnic groups: Kui, Lao, Khmer, and Yer.

The provincial seal shows Prasat Hin Ban Samo, a Khmer temple about 1,000 years old, in the Prang Ku District.

The six leaves of the flower symbolise the six original districts of the province: Khukhan, Kantharalak, Uthumphon Phisai, Kanthararom, Rasi Salai, and Khun Han.

As of 26 November 2019 there is one Sisaket Provincial Administration Organisation (ongkan borihan suan changwat) and 37 municipal (thesaban) areas in the province.