Sisouk was a member of the Na Champassak royal family or house.
He served as Secretary General of the Royal Government in the Kingdom of Laos.
[1] He served as Minister of Finance from 1965 to 1974 in Royal Lao Government.
In 1981, he became a key political leader of the resistance against the communist Lao PDR government, together with General Vang Pao.
He died in Vang Pao's house in Santa Ana, California, United States.