"Sister Fate" is a song by Sheila E. from the album Romance 1600.

The album version of the song features an organ and percussion intro and has a running time of 3:50; the single version omits the intro and has a running time of 3:39.

The video introduced a new image for Sheila E., dressed in a brocaded "cloud jacket" that harkened back to Prince's "cloud suit" from his contemporaneously (1985) released video "Raspberry Beret".

At the timestamp of 3:06 within the video, an image of Prince from "Raspberry Beret" is superimposed for one second over a newspaper graphic with the headline "WHO IS SHEILA E.'S MYSTERY LOVE?"

Because of the underperformance of "Sister Fate", the second single, "A Love Bizarre" (which featured Prince) was rush-released.