The sisters continue to work in schools and churches in the Black and indigenous communities of the United States.
The Third Plenary Council of Baltimore (1884), a meeting of all Catholic bishops in the United States, renewed the vigor for missionary work among the "Colored and Indian races".
For some years previous to this step, Drexel had been very active in re-establishing and supporting schools in many of the Indian reservations.
Early in 1892 a mother-house and novitiate were opened at Cornwells Heights, Pennsylvania, adjoining which was erected a manual training and boarding school for African-American boys and girls.
[2] In June 1894, four sisters set out for Santa Fe, New Mexico to reopen St. Catherine Indian School.
[6] Drexel's shrine remains active and is now managed by the Archdiocese of Philadelphia, who moved it to the Cathedral Basilica of Saints Peter and Paul in 2016.
[7][8] In 2017, due to a lack of members and money, the sisters moved out of St. Elizabeth's Convent and sold the property.